Earthquakes have repeatedly demonstrated the vulnerability of high-rise reinforced concrete (RCC) buildings, withdamageoften attributed to structural irregularities and inadequate design provisions. Among these, vertical irregularities—arisingfromnon-uniform distribution of stiffness, strength, or mass along the height—significantly compromise seismic performance. Theuseoffloating columns further aggravates this issue by disrupting the continuity of load transfer, thereby increasing susceptibilitytoearthquake-induced damage. This study investigates the seismic behaviour of a G+10 RCC building under Zone Vseismicconditions,considering both regular and vertically irregular configurations. Structural models were developed with and without floatingcolumns, and the influence of their placement at different peripheral positions was examined to identify critical locations. Seismicresponse was assessed using key parameters including base shear, storey drift, lateral displacement, shear force, andbendingmoments. Comparative analysis across the models highlights the adverse effects of floating columns on seismic performanceandprovides insights into their implications in high-rise construction. The findings aim to guide safer design practices forbuildingsincorporating vertical irregularities and floating columns. Keywords Floating Column, Vertical Irregularity, Seismic, Storey Drift, Base Shear, Bending Moment, Shear Force.