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 Special Issue on The Sustainable Development Goals

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Volume 8 , August,

Issue 8

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31 August 2025

Vol. 9,  Special Issue (Bi-yearly)



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“A Review on the Anticancer Activity of Marine Algae fromtheKonkanRegion Against Breast and Cervical Cancer Cell Lines’’

Abstract

Breast and cervical cancers continue to pose a significant health burden globally, particularly in developingcountriessuch as India, where access to effective and affordable treatments remains a challenge. In this context, the marine ecosystemhasemerged as a promising source of novel bioactive compounds with therapeutic potential. Among marine organisms, algaeareknown to produce a wide array of secondary metabolites with cytotoxic, antioxidant, and antiproliferative properties. Thisreviewaims to consolidate current research on the anticancer potential of marine algae, with a specific focus on algal speciesfoundalong the relatively underexplored Konkan coast of Maharashtra, India. The purpose of this review is to provide a comprehensiveoverview of the cytotoxic activity of marine algal extracts, particularly their effectiveness against MCF-7 (breast cancer)andHeLa (cervical cancer) cell lines. Studies have demonstrated mechanisms such as apoptosis induction, disruptionofmitochondrial function, generation of reactive oxygen species (ROS), and cell cycle arrest. These findings suggest that marinealgae from the Konkan region may harbor unique compounds with potent anticancer activity. In conclusion, marinealgaerepresent a valuable, yet underutilized, source of anticancer agents. While promising in vitro data exist, there is a needforfurtherresearch including compound isolation, mechanistic studies, and in vivo evaluations. Exploring the bioactive potential of Konkanalgae could pave the way for novel, cost-effective anticancer therapies. Keywords: Marine algae, Konkan coast, Breast cancer, HeLa cell line, Anticancer activity, Natural products, Cancer therapeutics

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