This study establishes a comprehensive methodology for the seismic analysis and design of transfer girders in G+9 and G+18 reinforced concrete structures with floating columns. Focusing on Zone III seismic conditions, the research addresses the critical performance challenges caused by vertical irregularities in high-rise buildings, where transfer systems introduce abrupt changes to lateral stiffness and load paths. Advanced analytical modeling was performed in ETABS 2021, featuring an innovative design strip element approach for transfer girders and modeling floating columns as shear wall elements to enhance lateral stiffness. The methodology integrated response spectrum analysis (IS 1893:2016), time history analysis, pushover analysis, and progressive collapse assessment (GSA guidelines). Key findings indicate that both building configurations maintained story drift ratios within permissible limits (0.0015-0.0038), and positioning girders at 20-30% of building height optimized performance by reducing force amplification by 20%. Modeling floating columns as shear walls reduced story drift by 35-45%. Ultimately, this research provides validated guidelines and practical design recommendations for developing safer and more economical high-rise buildings with transfer girder systems in seismic zones7. Keywords:Transfer Girders, Floating Columns, Seismic Analysis, Progressive Collapse, High-Rise Buildings, ETABS Modeling, Life Cycle Cost Analysis